| Disclosure of Compensation Related Costs, Share-based Payments [Abstract] | Period [Axis] |
|---|
2016-01-01 - 2016-12-31 |
|---|
Disclosure of Compensation Related Costs, Share-based Payments [Abstract] | |
Summary of details regarding stock options granted under equity incentive plans | The following table summarizes details regarding stock options granted under our equity incentive plans for the year ended December 31, 2016: | | | | | | | | | | | | | | | | December 31, 2016 | | Options | | Weighted Average Exercise Price | | Weighted Average Remaining Contractual Term | | Aggregate Intrinsic Value
($ in thousands) | Outstanding at beginning of year | 2,904,177 |
| | $ | 34.97 |
| | — |
| | $ | — |
| Granted | 784,048 |
| | 24.59 |
| | — |
| | — |
| Exercised | (155,705 | ) | | 17.99 |
| | — |
| | — |
| Expired and/or forfeited | (419,342 | ) | | 44.10 |
| | — |
| | — |
| Outstanding at end of year | 3,113,178 |
| | $ | 31.97 |
| | 7.4 |
| | $ | 28,113 |
| Outstanding at end of year - vested and unvested expected to vest | 2,915,930 |
| | $ | 31.53 |
| | 7.4 |
| | $ | 27,038 |
| Exercisable at end of year | 1,536,405 |
| | $ | 27.92 |
| | 6.3 |
| | $ | 17,928 |
|
The following table summarizes stock option activity during 2016: | | | | | | | | | | | | | | | | | 2007 Equity | | 2000 Equity | | 2013 Lumara | | Inducement | | | | Plan | | Plan | | Equity Plan | | Grants | | Total | Outstanding at December 31, 2015 | 1,963,162 |
| | 14,040 |
| | 96,000 |
| | 830,975 |
| | 2,904,177 |
| Granted | 581,648 |
| | — |
| | 92,400 |
| | 110,000 |
| | 784,048 |
| Exercised | (134,455 | ) | | — |
| | — |
| | (21,250 | ) | | (155,705 | ) | Expired or terminated | (251,533 | ) | | (8,840 | ) | | (54,219 | ) | | (104,750 | ) | | (419,342 | ) | Outstanding at December 31, 2016 | 2,158,822 |
| | 5,200 |
| | 134,181 |
| | 814,975 |
| | 3,113,178 |
|
|
Summary of details regarding restricted stock units granted under equity incentive plans | The following table summarizes RSU activity during 2016: | | | | | | | | | | | | | | | | | 2007 Equity | | 2000 Equity | | 2013 Lumara | | Inducement | | | | Plan | | Plan | | Equity Plan | | Grants | | Total | Outstanding at December 31, 2015 | 446,330 |
| | — |
| | 52,350 |
| | 155,675 |
| | 654,355 |
| Granted | 659,618 |
| | — |
| | 1,500 |
| | 64,500 |
| | 725,618 |
| Vested | (209,599 | ) | | — |
| | (16,749 | ) | | (74,219 | ) | | (300,567 | ) | Expired or terminated | (122,545 | ) | | — |
| | (9,407 | ) | | (10,500 | ) | | (142,452 | ) | Outstanding at December 31, 2016 | 773,804 |
| | — |
| | 27,694 |
| | 135,456 |
| | 936,954 |
|
The following table summarizes details regarding RSUs granted under our equity incentive plans for the year ended December 31, 2016: | | | | | | | | | December 31, 2016 | | Restricted Stock Units | | Weighted Average Grant Date Fair Value | Outstanding at beginning of year | 654,355 |
| | $ | 36.90 |
| Granted | 725,618 |
| | 22.28 |
| Vested | (300,567 | ) | | 30.38 |
| Forfeited | (142,452 | ) | | 26.66 |
| Outstanding at end of year | 936,954 |
| | $ | 28.78 |
| Outstanding at end of year and expected to vest | 781,165 |
| | $ | 28.79 |
|
|
Schedule of equity-based compensation expense | Equity-based compensation expense for 2016, 2015 and 2014 consisted of the following (in thousands): | | | | | | | | | | | | | | Years Ended December 31, | | 2016 | | 2015 | | 2014 | Cost of product sales and services | $ | 520 |
| | $ | 371 |
| | $ | 122 |
| Research and development | 3,476 |
| | 2,992 |
| | 1,596 |
| Selling, general and administrative | 18,547 |
| | 13,874 |
| | 6,907 |
| Total equity-based compensation expense | $ | 22,543 |
| | $ | 17,237 |
| | $ | 8,625 |
| Income tax effect | (6,232 | ) | | (4,885 | ) | | — |
| After-tax effect of equity-based compensation expense | $ | 16,311 |
| | $ | 12,352 |
| | $ | 8,625 |
|
|
Schedule of share-based payment award, stock options, valuation assumptions | The following table summarizes the weighted average assumptions we utilized for purposes of valuing grants of options to our employees and non-employee directors: | | | | | | | | | | | | | | Years Ended December 31, | | 2016 | | 2015 | | 2014 | | | | Non-Employee | | | | Non-Employee | | | | Non-Employee | | Employees | | Directors | | Employees | | Directors | | Employees | | Directors | Risk free interest rate (%) | 1.32 | | 1.10 | | 1.55 | | 1.24 | | 1.56 | | 1.28 | Expected volatility (%) | 49 | | 54 | | 47 | | 46 | | 47 | | 46 | Expected option term (years) | 5.00 | | 3.00 | | 5.00 | | 4.00 | | 5.00 | | 4.00 | Dividend yield | none | | none | | none | | none | | none | | none |
|