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090122 - Disclosure - Organization and Significant Accounting Policies, Fair Value Measurements Using Significant Unobservable Inputs (Level 3) (Details)
(http://isispharm.com/role/OrganizationAndSignificantAccountingPoliciesFairValueMeasurementsUsingSignificantUnobservableInputsLevel3Details)
TableFair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Table]
Slicers (applies to each fact value in each table cell)
Reporting Entity [Axis]0000874015 (http://www.sec.gov/CIK)
Asset Class [Axis]Equity Securities [Member]
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]Period [Axis]
2015-01-01 - 2015-12-31
Unobservable Inputs (Level 3) [Roll Forward]
 
Beginning balance of Level 3 investments
81,881,000  
Transfers into Level 3 investments
0  
Total gains (losses) included in accumulated other comprehensive income (loss)
22,377,000  
Transfers out of Level 3 investments
(104,258,000) 
Ending balance of Level 3 investments
0