| Income Tax Disclosure [Abstract] | Period [Axis] |
|---|
2015-01-01 - 2015-12-31 |
|---|
Income Tax Disclosure [Abstract] | |
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block] |
|
|
Years Ended December 31, |
| |
|
2015 |
|
2014 |
|
2013 |
| United States |
|
$ |
(193,128 |
) |
|
$ |
10,847 |
|
|
$ |
(216,583 |
) |
| Foreign |
|
|
(24,457 |
) |
|
|
(5,275 |
) |
|
|
(19,171 |
) |
| Income (loss) before income taxes and loss from investment in affiliate |
|
$ |
(217,585 |
) |
|
$ |
5,572 |
|
|
$ |
(235,754 |
) |
|
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block] |
|
|
Years Ended December 31, |
| |
|
2015 |
|
2014 |
|
2013 |
| Current: |
|
|
|
|
|
|
| Federal |
|
$ |
— |
|
|
$ |
— |
|
|
$ |
— |
|
| State |
|
|
— |
|
|
|
— |
|
|
|
— |
|
| Foreign |
|
|
468 |
|
|
|
495 |
|
|
|
(847 |
) |
| Total current provision (benefit) |
|
|
468 |
|
|
|
495 |
|
|
|
(847 |
) |
| Deferred: |
|
|
|
|
|
|
|
|
|
|
|
|
| Federal |
|
|
— |
|
|
|
— |
|
|
|
— |
|
| State |
|
|
— |
|
|
|
— |
|
|
|
— |
|
| Foreign |
|
|
— |
|
|
|
— |
|
|
|
— |
|
| Total deferred provision (benefit) |
|
|
— |
|
|
|
— |
|
|
|
— |
|
| Total provision (benefit) for income taxes |
|
$ |
468 |
|
|
$ |
495 |
|
|
$ |
(847 |
) |
|
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block] |
| |
|
Years Ended December 31, |
| |
|
2015 |
|
2014 |
|
2013 |
| Statutory tax rate |
|
|
(34.0 |
)% |
|
|
(34.0 |
)% |
|
|
(34.0 |
)% |
| State tax rate, net of federal benefit |
|
|
(0.3 |
)% |
|
|
23.3 |
% |
|
|
(0.7 |
)% |
| Stock-based compensation |
|
|
0.1 |
% |
|
|
(2.8 |
)% |
|
|
0.1 |
% |
| Federal R&D credit |
|
|
(0.6 |
)% |
|
|
31.0 |
% |
|
|
(0.8 |
)% |
| Derivative liabilities |
|
|
3.6 |
% |
|
|
541.5 |
% |
|
|
13.9 |
% |
| Non-Deductible Interest |
|
|
5.5 |
% |
|
|
— |
% |
|
|
0.0 |
% |
| Other |
|
|
0.1 |
% |
|
|
(7.8 |
)% |
|
|
(0.6 |
)% |
| Foreign losses |
|
|
(1.2 |
)% |
|
|
32.3 |
% |
|
|
(1.4 |
)% |
| Change in valuation allowance |
|
|
27.1 |
% |
|
|
(592.4 |
)% |
|
|
23.1 |
% |
| Effective income tax rate |
|
|
0.3 |
% |
|
|
(8.9 |
)% |
|
|
(0.4 |
)% |
|
Schedule of Deferred Tax Assets and Liabilities [Table Text Block] |
| |
|
December 31, |
| |
|
2015 |
|
2014 |
|
2013 |
| Net operating loss carryforwards |
|
$ |
207,241 |
|
|
$ |
195,536 |
|
|
$ |
167,354 |
|
| Fixed assets |
|
|
10,519 |
|
|
|
1,299 |
|
|
|
822 |
|
| Research and development credits |
|
|
16,612 |
|
|
|
14,701 |
|
|
|
11,654 |
|
| Foreign Tax Credit |
|
|
1,899 |
|
|
|
1,431 |
|
|
|
935 |
|
| Accruals and reserves |
|
|
26,366 |
|
|
|
16,425 |
|
|
|
17,893 |
|
| Stock-based compensation |
|
|
19,048 |
|
|
|
18,773 |
|
|
|
17,521 |
|
| Capitalized start-up costs |
|
|
9,568 |
|
|
|
13,095 |
|
|
|
15,133 |
|
| Capitalized research and development costs |
|
|
63,339 |
|
|
|
56,880 |
|
|
|
45,968 |
|
| Other |
|
|
9,999 |
|
|
|
6,700 |
|
|
|
6,741 |
|
| Total deferred tax assets |
|
|
364,591 |
|
|
|
324,840 |
|
|
|
284,021 |
|
| Fixed assets |
|
|
— |
|
|
|
— |
|
|
|
— |
|
| Debt discount and derivative |
|
|
(4,402 |
) |
|
|
(12,517 |
) |
|
|
— |
|
| Total deferred tax liabilities |
|
|
(4,402 |
) |
|
|
(12,517 |
) |
|
|
— |
|
| Net deferred tax asset prior to valuation allowance |
|
|
360,189 |
|
|
|
312,323 |
|
|
|
284,021 |
|
| Less: Valuation allowance |
|
|
(360,189 |
) |
|
|
(312,323 |
) |
|
|
(284,021 |
) |
| Net deferred tax assets (liabilities) |
|
$ |
— |
|
|
$ |
— |
|
|
$ |
— |
|
|
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block] |
| Balance at December 31, 2012 |
|
$ |
3,918 |
|
| Increases in tax positions for prior period |
|
|
469 |
|
| Increases in tax positions during current period |
|
|
1,693 |
|
| Balance at December 31, 2013 |
|
$ |
6,080 |
|
| Increases in tax positions for prior period |
|
|
4,736 |
|
| Increases in tax positions during current period |
|
|
6,265 |
|
| Balance at December 31, 2014 |
|
$ |
17,081 |
|
| Decreases in tax positions for prior period |
|
|
(9,404 |
) |
| Increases in tax positions during current period |
|
|
957 |
|
| Balance at December 31, 2015 |
|
$ |
8,634 |
|
|