| Disclosure of Compensation Related Costs, Share-based Payments [Abstract] | Period [Axis] |
|---|
2016-01-01 - 2016-12-31 |
|---|
Disclosure of Compensation Related Costs, Share-based Payments [Abstract] | |
Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block] |
A summary of options at December 31, 2016 and activity during the two years then ended is presented below:
| |
|
Shares
|
|
|
Weighted-
Average
Exercise Price
|
|
|
Weighted-
Average
Remaining
Contractual
Term (in years)
|
|
| |
|
|
|
|
|
|
|
|
|
|
Options outstanding at January 1, 2015
|
|
|
66,933
|
|
|
$
|
56.00
|
|
|
|
8.9
|
|
|
Granted
|
|
|
489,116
|
|
|
$
|
1.98
|
|
|
|
10.0
|
|
|
Exercised
|
|
|
—
|
|
|
|
|
|
|
|
|
|
|
Forfeited/Expired
|
|
|
(229
|
)
|
|
$
|
5,103.28
|
|
|
|
|
|
|
Options outstanding at December 31, 2015
|
|
|
555,820
|
|
|
$
|
6.43
|
|
|
|
9.6
|
|
|
Granted
|
|
|
23,000,000
|
|
|
$
|
0.02
|
|
|
|
10.0
|
|
|
Exercised
|
|
|
—
|
|
|
|
|
|
|
|
|
|
|
Forfeited/Expired
|
|
|
(43
|
)
|
|
$
|
1,960.39
|
|
|
|
|
|
|
Options outstanding at December 31, 2016
|
|
|
23,555,777
|
|
|
$
|
0.03
|
|
|
|
9.7
|
|
|
Options exercisable at December 31, 2016
|
|
|
8,380,503
|
|
|
$
|
0.06
|
|
|
|
9.7
|
|
|
Available for grant at December 31, 2016
|
|
|
9,383,070
|
|
|
|
|
|
|
|
|
|
|
Schedule of Share-based Compensation, Shares Authorized under Stock Option Plans, by Exercise Price Range [Table Text Block] |
The following information applies to options outstanding and exercisable at December 31, 2016:
|
Exercise
Price
|
|
|
Number
Outstanding
|
|
|
Option Outstanding Options Average Remaining Contractual Life (years)
|
|
|
Weighted Average
Exercise price
|
|
|
Number
Exercisable
|
|
|
Options Exercisable Weighted Average
Exercise price
|
|
|
$
|
0.0196
|
|
|
|
22,850,000
|
|
|
|
9.72
|
|
|
$
|
0.0196
|
|
|
|
7,850,000
|
|
|
$
|
0.0196
|
|
| |
0.15402
|
|
|
|
705,412
|
|
|
|
8.74
|
|
|
|
0.15402
|
|
|
|
530,213
|
|
|
|
0.15402
|
|
| |
19.32
|
|
|
|
150
|
|
|
|
7.85
|
|
|
|
19.32
|
|
|
|
75
|
|
|
|
19.32
|
|
| |
70.00
|
|
|
|
100
|
|
|
|
4.66
|
|
|
|
70.00
|
|
|
|
100
|
|
|
|
70.00
|
|
| |
210.00
|
|
|
|
40
|
|
|
|
4.62
|
|
|
|
210.00
|
|
|
|
40
|
|
|
|
210.00
|
|
| |
680.00
|
|
|
|
40
|
|
|
|
3.11
|
|
|
|
680.00
|
|
|
|
40
|
|
|
|
680.00
|
|
| |
5,250.00
|
|
|
|
35
|
|
|
|
1.30
|
|
|
|
5,250.00
|
|
|
|
35
|
|
|
|
5,250.00
|
|
|
Total
|
|
|
|
23,555,777
|
|
|
|
9.69
|
|
|
$
|
0.033
|
|
|
|
8,380,503
|
|
|
$
|
0.05529
|
|
|
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block] |
A summary of common stock purchase warrants at December 31, 2016 and activity during the two years ended December 31, 2016 is presented below:
| |
|
Shares
|
|
|
Weighted-
Average
Exercise
Price
|
|
|
Weighted-
Average
Remaining
Contractual
Term (in years)
|
|
|
Outstanding at January 1, 2015
|
|
|
150,620
|
|
|
$
|
170.00
|
|
|
|
6.6
|
|
|
Issued
|
|
|
2,072
|
|
|
$
|
19.98
|
|
|
|
8.18
|
|
|
Exercised
|
|
|
-
|
|
|
|
|
|
|
|
|
|
|
Expired
|
|
|
(13,325
|
)
|
|
$
|
24.00
|
|
|
|
|
|
|
Outstanding at December 31, 2015
|
|
|
139,367
|
|
|
$
|
182.26
|
|
|
|
6.3
|
|
|
Issued
|
|
|
-
|
|
|
|
|
|
|
|
|
|
|
Exercised
|
|
|
-
|
|
|
|
|
|
|
|
|
|
|
Expired
|
|
|
(222
|
)
|
|
$
|
5,966.40
|
|
|
|
|
|
|
Outstanding at December 31, 2016
|
|
|
139,145
|
|
|
$
|
173.03
|
|
|
|
5.5
|
|
|
Exercisable at December 31, 2016
|
|
|
135,600
|
|
|
$
|
89.42
|
|
|
|
5.5
|
|
|
Schedule of Warrants or Rights, Shares Authorized, by Exercise Price Range [Table Text Block] |
The following information applies to common stock purchase warrants outstanding and exercisable at December 31, 2016:
| |
|
|
Warrants Outstanding
|
|
|
Warrants Exercisable
|
|
| |
|
|
Shares
|
|
|
Weighted-
Average
Remaining
Contractual
Term
|
|
|
Weighted-
Average
Exercise
Price
|
|
|
Shares
|
|
|
Weighted-
Average
Exercise
Price
|
|
|
$
|
0.01 – $20.00
|
|
|
|
94,108
|
|
|
|
6.0
|
|
|
$
|
15.54
|
|
|
|
94,108
|
|
|
$
|
15.54
|
|
|
$
|
20.01 – $30.00
|
|
|
|
29,743
|
|
|
|
5.1
|
|
|
$
|
24.52
|
|
|
|
28,743
|
|
|
$
|
24.62
|
|
|
$
|
30.01 – $40.00
|
|
|
|
628
|
|
|
|
0.6
|
|
|
$
|
40.00
|
|
|
|
628
|
|
|
$
|
40.00
|
|
|
$
|
40.01 - $50.00
|
|
|
|
6,253
|
|
|
|
2.9
|
|
|
$
|
48.36
|
|
|
|
5,253
|
|
|
$
|
48.41
|
|
|
$
|
50.01 – $60.00
|
|
|
|
543
|
|
|
|
4.6
|
|
|
$
|
60.00
|
|
|
|
543
|
|
|
$
|
60.00
|
|
|
$
|
>60.00
|
|
|
|
7,870
|
|
|
|
3.3
|
|
|
$
|
2,735.01
|
|
|
|
6,325
|
|
|
$
|
1,524.67
|
|
| |
|
|
|
|
139,145
|
|
|
|
5.5
|
|
|
$
|
173.03
|
|
|
|
135,600
|
|
|
$
|
89.42
|
|
|