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127 - Disclosure - Share-Based Payments (Tables)
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Reporting Entity [Axis]0001439222 (http://www.sec.gov/CIK)
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]Period [Axis]
2016-01-01 - 2016-12-31
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]
 
Summary of Company's Stock Option Activity of all Stock Incentive Plans

The following table summarizes the stock option activity of all stock incentive plans for the year ended December 31, 2016.

 

     Number of
Stock
Options		     Weighted-
Average
Exercise
Price		      Weighted-
Average
Remaining
Contractual
Term
(in years)		      Aggregate
Intrinsic
Value (in
thousands)		  

Outstanding at December 31, 2015

      4,618,697      $ 44.45         7.49       $ 153,573   

Granted

      1,556,240        43.99         

Exercised

      (603,359 )          10.84         

Forfeited/Expired

      (352,698 )      65.21         
  

 

 

          

Outstanding at December 31, 2016

      5,218,880      $ 46.79         7.28       $ 63,559   
  

 

 

          

Exercisable at December 31, 2016

        2,527,605      $ 36.50         5.85       $ 53,952   
  

 

 

          

Vested and expected to vest at December 31, 2016

      5,065,064      $ 46.43                   7.23       $         63,351   
  

 

 

          
  
Unvested Stock Unit Activity

The following table presents RSU activity for the year ended December 31, 2016:

 

     Number of
Stock Units		      Weighted-average
grant date fair value		  

Unvested shares at December 31, 2015

      15,000       $ 122.22   

Granted

      69,550         41.77   

Vested

      (7,500 )       122.22   
  

 

 

     

 

 

  

Unvested shares at December 31, 2016

      77,050       $ 49.60   
  

 

 

     

 

 

  
  
Schedule of Performance-Based Units

The following table presents PSU activity for the year ended December 31, 2016:

 

     Number of
Stock Units		      Weighted-average
grant date fair value		  

Unvested shares at December 31, 2015

      100,270       $ 64.44   

Granted

      114,503         45.02   

Vested

      —           —     

Forfeited/expired

      (14,160 )       64.44   
  

 

 

     

 

 

  

Unvested shares at December 31, 2016

      200,613       $ 53.36   
  

 

 

     

 

 

  
  
Stock-Based Compensation Expense for Employee and Non-Employee Stock Options, Restricted Stock Units, Performance-Based Stock Options, Performance-Based Stock Units and Employee Stock Purchase Plan Shares

During the years ended December 31, 2016, 2015 and 2014, the Company recorded stock-based compensation expense for employee and non-employee stock options, restricted stock units, performance-based stock options, performance-based stock units and employee stock purchase plan shares. Expenses related to these equity-based awards were allocated as follows in the consolidated statements of operations (in thousands):

 

     Years Ended December 31,  
     2016      2015      2014  

Research and development expense

    $ 25,386       $ 17,419       $ 6,688   

General and administrative expense

      16,700         14,544         4,818   
  

 

 

     

 

 

     

 

 

  
   $     42,086       $     31,963       $     11,506   
  

 

 

     

 

 

     

 

 

  
  
Schedule of Grant Date Fair Value Option Award Weighted Average Assumptions Used

The following table summarizes the weighted average assumptions used in calculating the grant date fair value of the awards:

 

     Years Ending December 31,  
     2016     2015     2014  

Risk-free interest rate

              1.42 %              1.71 %              1.83 % 

Expected dividend yield

      —          —          —     

Expected term (in years)

      6.05        6.04        6.03   

Expected volatility

      72.84 %      69.62 %      78.61 %