Slicers (applies to each fact value in each table cell)

Reporting Entity [Axis]

0001510580 (http://www.sec.gov/CIK)

Income Tax Disclosure [Abstract]	Period [Axis]
	2016-01-01 - 2016-12-31
Income Tax Disclosure [Abstract]
Composition of Income Tax (Expense) Benefit from Continuing Operations	The composition of our income tax expense (benefit) from continuing operations for the years ended December 31, 2016, 2015, and 2014, was as follows (in thousands):   Current   Deferred   Total Year ended December 31, 2016           U.S. Federal $ —   $ —   $ — State 1   —   1 Foreign —   (2,895 )   (2,895 ) Total 1   (2,895 )   (2,894 ) Year ended December 31, 2015           U.S. Federal $ —   $ —   $ — State 1   —   1 Foreign —   —   — Total 1   —   1 Year ended December 31, 2014           U.S. Federal $ —   $ —   $ — State 1   —   1 Foreign —   —   — Total 1   —   1
Reconciles of Income Tax Rate from Continuing Operations to the Federal Statutory Tax Rate	The following table reconciles the Company's effective income tax rate from continuing operations to the federal statutory tax rate of 34%:   YEAR ENDED DECEMBER 31,   2016   2015   2014 Federal income taxes 34.00  %   34.00  %   34.00  % State income taxes, net of federal benefit 6.17  %   3.77  %   5.08  % Foreign rate differential (14.69 )%   (3.51 )%   —  % Meals and entertainment (0.03 )%   (0.04 )%   (0.06 )% Stock Compensation (0.55 )%   (2.27 )%   (4.41 )% Non-cash interest —  %   —  %   (0.53 )% Net operating losses expiring due to Section 382 limitation —  %   (1.36 )%   —  % Return to provision difference (0.07 )%   (0.21 )%   —  % ASC 740-10 (4.07 )%   (8.11 )%   —  % Other permanent differences 0.17  %   0.13  %   —  % Change in valuation allowance (19.86 )%   (22.40 )%   (28.85 )% Prior period true up —  %   —  %   (5.23 )% Income tax benefits from continuing operations 1.07  %   —  %   —  %
Components of Deferred Tax Assets	As of December 31, 2016 and 2015, the tax effects of temporary differences that gave rise to significant portions of deferred tax assets and deferred tax liabilities were:    DECEMBER 31,   2016   2015 Deferred tax assets - noncurrent:       Deferred rent $ 2,305   $ 754 Net operating loss and other carryforwards 66,702   5,582 Stock compensation 34,129   14,974 Accrued compensation 5,236   2,234 Deferred revenue 14,883   21,205 Collaboration agreements 6,485   — Other 679   351 Less: valuation allowance (111,835 )   (40,164 ) Total deferred tax assets - noncurrent 18,584   4,936 Deferred tax liabilities - noncurrent:       Section 481 adjustment (1,319 )   (19 ) Fixed assets (2,334 )   (1,254 ) Intangible assets (1,682 )   (3,201 ) Deferred state taxes (13,249 )   (3,307 ) Total deferred tax liabilities - noncurrent (18,584 )   (7,781 ) Net deferred tax assets/(liabilities) - noncurrent $ —   $ (2,845 )
Summary of Activity Related to Unrecognized Tax Benefit	The following table summarizes the activity related to uncertain tax benefits for 2016, 2015, and 2014, excluding any interest or penalties:   FOR THE YEAR ENDED DECEMBER 31,   2016   2015   2014 Balance as of January 1 $ 10,392   $ —   $ — Gross increases - tax positions in prior periods 1,379   —   — Gross decreases - tax positions in prior periods (2,143 )   —   — Gross increases - tax positions in current periods 9,628   10,392   — Gross decreases - tax positions in current periods —   —   — Net unrecognized tax benefits as of December 31 $ 19,256   $ 10,392   $ —