| | | As of December 31, | | ||||
| | | 2017 | | 2016 | | ||
| Deferred tax assets: | | | | | | | |
| Net-operating loss carryforward | | $ | 43,577,000 | | $ | 59,926,000 | |
| Stock-based compensation | | | 5,726,000 | | | 9,279,000 | |
| In-Process R&D | | | 2,259,000 | | | 4,050,000 | |
| Deferred revenue | | | 11,064,000 | | | - | |
| R&D credit | | | 5,604,000 | | | 3,962,000 | |
| Change in unrealized loss on marketable securities | | | 46,000 | | | 178,000 | |
| Other | | | 314,000 | | | 316,000 | |
| Total Deferred Tax Assets | | | 68,590,000 | | | 77,711,000 | |
| Valuation allowance | | | (63,718,000) | | | (77,711,000) | |
| Deferred Tax Asset, Net of Allowance | | $ | 4,872,000 | | $ | - | |
| In-process research and development (Assembly Merger) | | | 7,007,802 | | | 11,119,651 | |
| Net Deferred Tax Liability | | $ | 2,135,802 | | $ | 11,119,651 | |
| | | As of December 31, | | |||||||
| | | 2017 | | 2016 | | 2015 | | |||
| Statutory Federal Income Tax Rate | | | (34.0) | % | | (34.0) | % | | (34.0) | % |
| State Taxes, Net of Federal Tax Benefit | | | (2.6) | % | | (4.3) | % | | (11.0) | % |
| Merger Cost | | | - | % | | - | % | | 0.9 | % |
| Stock based Compensation | | | - | % | | 3.4 | % | | 16.7 | % |
| Credits | | | (2.1) | % | | (1.8) | % | | - | % |
| Federal Rate Change | | | 47.7 | % | | - | % | | - | % |
| State Rate Change | | | 0.2 | % | | 7.5 | % | | - | % |
| Other | | | 0.3 | % | | 2.3 | % | | 0.1 | % |
| Change in Valuation Allowance | | | (27.0) | % | | 25.5 | % | | 27.3 | % |
| Income Taxes Provision (Benefit) | | | (17.5) | % | | (1.4) | % | | - | % |