| (7) | Income Taxes |
| (a) | Income Tax Expense |
| | | December 31, | | |||||||
| | | 2017 | | 2016 | | 2015 | | |||
| | | | | | | | | | | |
| U.S. federal | | $ | - | | $ | - | | $ | - | |
| State and local | | | 700 | | | 752 | | | 200 | |
| Deferred | | | - | | | - | | | - | |
| Total | | $ | 700 | | $ | 752 | | $ | 200 | |
| (b) | Tax Rate Reconciliation |
| | | December 31, | | |||||||
| | | 2017 | | 2016 | | 2015 | | |||
| | | | | | | | | | | |
| Computed "expected" tax expense (benefit) | | $ | (7,133,934) | | $ | (6,450,075) | | $ | (6,190,781) | |
| Increase (reduction) in income taxes resulting from: | | | | | | | | | | |
| Change in valuation allowance | | | (6,173,708) | | | 6,709,591 | | | 6,691,992 | |
| Difference associated with federal rate change | | | 13,240,342 | | | - | | | - | |
| State and local income taxes, net of federal income tax benefit | | | 462 | | | 496 | | | 132 | |
| Stock expense | | | 684,854 | | | 200,002 | | | 102,221 | |
| Research and development tax credits | | | (394,470) | | | (337,968) | | | (452,609) | |
| Orphan drug tax credit | | | (227,109) | | | (127,641) | | | (155,452) | |
| Other, net | | | 4,263 | | | 6,347 | | | 4,697 | |
| | | $ | 700 | | $ | 752 | | $ | 200 | |
| | (c) | Significant Components of Deferred Taxes |
| | | December 31, | | ||||
| | | 2017 | | 2016 | | ||
| | | | | | | | |
| Deferred tax assets: | | | | | | | |
| Stock-based compensation | | $ | 1,330,706 | | $ | 1,924,260 | |
| Net operating loss carryforwards | | | 25,395,518 | | | 30,700,358 | |
| Employee benefits | | | 54,729 | | | 69,112 | |
| Research and development tax credits | | | 3,012,081 | | | 2,465,893 | |
| Orphan drug tax credits | | | 1,023,290 | | | 679,185 | |
| Other deductible tempory differences | | | 104 | | | 70,231 | |
| Total gross deferred tax assets | | | 30,816,428 | | | 35,909,039 | |
| Less valuation allowance | | | (30,813,270) | | | (35,904,927) | |
| Net deferred tax assets | | | 3,158 | | | 4,112 | |
| Deferred tax liabilities: | | | | | | | |
| Plant and equipment | | | (3,158) | | | (4,112) | |
| Total gross deferred tax liabilities | | | (3,158) | | | (4,112) | |
| Net deferred tax liabilities | | $ | - | | $ | - | |
| | | December 31, | | ||||
| | | 2017 | | 2016 | | ||
| | | | | | | | |
| Balance, beginning of year | | $ | - | | $ | - | |
| | | | | | | | |
| Balance, end of year | | $ | - | | $ | - | |