| | | 2017 | | 2016 | | ||
| | | | | | | | |
| Tax provision (benefit) | | | | | | | |
| Current | | | | | | | |
| Federal | | $ | | | $ | | |
| State | | | | | | | |
| Total current | | | | | | | |
| | | | | | | | |
| Deferred | | | | | | | |
| Federal | | | 13,626,404 | | | (4,053,114) | |
| State | | | 1,969,262 | | | 99,883 | |
| Total deferred | | | 15,595,666 | | | (3,953,231) | |
| | | | | | | | |
| Change in valuation allowance | | | (15,595,666) | | | 3,953,231 | |
| Total | | $ | | | $ | | |
| | | 2017 | | 2016 | | ||
| | | | | | | | |
| Deferred tax assets | | | | | | | |
| Federal net operating loss | | $ | 24,353,504 | | $ | 36,472,996 | |
| Federal research and development tax credit carryforwards | | | 4,947,879 | | | 3,808,862 | |
| State net operating losses and tax credit carryforwards | | | 1,589,927 | | | 2,628,006 | |
| Capitalized research and development expenses | | | 5,772,165 | | | 8,834,640 | |
| Stock-based compensation expense | | | 1,445,078 | | | 2,162,703 | |
| Depreciable assets | | | 166,793 | | | | |
| Other | | | 121,680 | | | 235,681 | |
| Total deferred tax assets | | | 38,397,026 | | | 54,142,888 | |
| | | | | | | | |
| Deferred tax liabilities | | | | | | | |
| Depreciable assets | | | | | | (150,196) | |
| Total deferred tax liabilities | | | | | | (150,196) | |
| | | | | | | | |
| Net deferred tax assets | | | 38,397,026 | | | 53,992,692 | |
| Less valuation allowance | | | (38,397,026) | | | (53,992,692) | |
| Total deferred tax assets | | $ | | | $ | | |
| | | Year ended December 31, | | ||||
| | | 2017 | | 2016 | | ||
| Income tax benefit using U.S. federal statutory rate | | | 34.00 | % | | 34.00 | % |
| State income taxes | | | (9.58) | % | | (1.07) | % |
| Permanent items | | | (2.55) | % | | 17.88 | % |
| Federal tax credits | | | 8.43 | % | | 9.55 | % |
| Change in valuation allowance | | | 115 | % | | (63.97) | % |
| Federal rate change | | | (143.50) | % | | | |
| Other | | | (1.80) | % | | 3.61 | % |
| Total | | | 0.00 | % | | 0.00 | % |