Entity information:

14. Income Taxes

 

2017 U.S. Tax Reform

 

On December 22, 2017 President Trump signed into law the “Tax Cuts and Jobs Act” (“TCJA”) that significantly reforms the Internal Revenue Code of 1986, as amended. The TCJA, among other things, contains significant changes to corporate taxation, including reduction of the corporate tax rate from a top marginal rate of 35% to a flat rate of 21% effective as of January 1, 2018. Additionally, the TCJA contained provisions for the limitation of the tax deduction for interest expense; limitation of the deduction for net operating losses to 80% of current year taxable income and elimination of net operating loss carrybacks in each case for losses arising in taxable years beginning after December 31, 2017(though any such tax losses may be carried forward indefinitely); and modifying or repealing many business deductions and credits.  This includes reducing the business tax credit for certain clinical testing expenses incurred in the testing of certain drugs for rare disease or conditions generally referred to as ‘orphan drugs’.

 

The staff of the Securities and Exchange Commission issued Staff Accounting Bulletin No. 118 to address the application of U.S. GAAP in situations when a registrant does not have the necessary information available, prepared or analyzed (including computations) in reasonable detail to complete the accounting for certain income tax effects of the TCJA. In connection with the initial analysis of the impact of the TCJA, the Company remeasured its deferred tax assets and liabilities based on the rates at which they are expected to reverse in the future, which is generally 21%. The remeasurement of the Company’s deferred tax assets and liabilities was offset by a corresponding change in the valuation allowance.

 

The Company is still in the process of analyzing the impact to the Company of the TCJA. Where the Company has been able to make reasonable estimates of the effects the Company has recorded provisional amounts. The ultimate impact to the Company’s financial statements of the TCJA may differ from the provisional amounts due to, among other things, additional analysis, changes in interpretations and assumptions the Company has made, additional regulatory guidance that may be issued, and actions the Company may take as a result of the TCJA. The accounting is expected to be complete when the Company’s 2017 U.S. corporate income tax return is filed in 2018.

 

Income Taxes

 

During the years ended December 31, 2017, 2016 and 2015, the Company recorded no income tax benefits for the net operating losses incurred or the research and development tax credits generated in each year, due to its uncertainty of realizing a benefit from those items.

 

A reconciliation of the U.S. federal statutory income tax rate to the Company’s effective income tax rate is as follows:

 

 

 

 

 

 

 

 

 

 

 

Year Ended December 31, 

 

 

    

2017

    

2016

    

2015

 

Federal statutory income tax rate

 

(34.0)

%  

(34.0)

%  

(34.0)

%

Tax reform change

 

43.0

 

 —

 

 —

 

Research and development tax credits

 

(3.3)

 

(2.9)

 

(3.1)

 

State taxes, net of federal benefit

 

(3.8)

 

(4.8)

 

(2.0)

 

Stock-based compensation

 

2.2

 

1.4

 

1.2

 

Other

 

(0.2)

 

(0.6)

 

(0.2)

 

Change in deferred tax asset valuation allowance

 

(3.9)

 

40.9

 

38.1

 

Effective income tax rate

 

 —

%  

 —

%  

 —

%

 

Net deferred tax assets consisted of the following:

 

 

 

 

 

 

 

 

 

 

December 31, 

 

    

2017

    

2016

Net operating loss carryforwards

 

$

33,094

 

$

31,960

Tax credit carryforwards

 

 

7,971

 

 

5,482

Capitalized start-up costs

 

 

1,022

 

 

1,723

Capitalized research and development expenses, net

 

 

21,869

 

 

26,943

Accrued expenses and other temporary differences

 

 

3,770

 

 

4,128

Total gross deferred tax assets

 

 

67,726

 

 

70,236

Valuation allowance

 

 

(67,726)

 

 

(70,236)

Net deferred tax assets

 

$

 —

 

$

 —

 

Changes in the valuation allowance for deferred tax assets during the years ended December 31, 2017, 2016 and 2015 related primarily to the increase in net operating loss carryforwards, capitalized research and development expenses and research and development tax credit carryforwards offset in 2017 by a decrease in a deferred tax asset resulting from the decreased federal corporate tax rate and were as follows:

 

 

 

 

 

 

 

 

 

 

 

 

 

Year Ended December 31, 

 

    

2017

    

2016

    

2015

Valuation allowance as of beginning of year

 

$

70,236

 

$

51,969

 

$

36,825

Increases recorded to income tax provision

 

 

24,773

 

 

18,267

 

 

15,144

Decreases recorded to income tax provision

 

 

(27,283)

 

 

 —

 

 

 —

Valuation allowance as of end of year

 

$

67,726

 

$

70,236

 

$

51,969

 

As of December 31, 2017, the Company had net operating loss carryforwards for federal and state income tax purposes of $126,229 and $109,258, respectively, which begin to expire in 2026 and 2026, respectively. As of December 31, 2017, the Company also had available research and development tax credit carryforwards for federal and state income tax purposes of $5,518 and $2,813, respectively, which begin to expire in 2026 and 2025, respectively. Utilization of the net operating loss carryforwards and research and development tax credit carryforwards may be subject to a substantial annual limitation under Section 382 of the Internal Revenue Code of 1986 due to ownership changes that have occurred previously or that could occur in the future. These ownership changes may limit the amount of carryforwards that can be utilized annually to offset future taxable income. In general, an ownership change, as defined by Section 382, results from transactions increasing the ownership of certain shareholders or public groups in the stock of a corporation by more than 50% over a three-year period. The Company has not conducted a study to assess whether a change of control has occurred or whether there have been multiple changes of control since inception due to the significant complexity and cost associated with such a study. If the Company has experienced a change of control, as defined by Section 382, at any time since inception, utilization of the net operating loss carryforwards or research and development tax credit carryforwards would be subject to an annual limitation under Section 382, which is determined by first multiplying the value of the Company’s stock at the time of the ownership change by the applicable long-term tax-exempt rate, and then could be subject to additional adjustments, as required. Any limitation may result in expiration of a portion of the net operating loss carryforwards or research and development tax credit carryforwards before utilization. Further, until a study is completed and any limitation is known, no amounts are being presented as an uncertain tax position.

 

The Company has evaluated the positive and negative evidence bearing upon its ability to realize the deferred tax assets. Management considered the Company’s cumulative net losses and concluded that it is more likely than not that the Company would not realize the benefits of the deferred tax assets. Accordingly, a full valuation allowance was established against the net deferred tax assets as of December 31, 2017 and 2016.  The valuation allowance, on a net basis, decreased by approximately $2,510 in 2017 primarily as a result of the decrease in the corporate tax rate offset by increase in deferred tax assets primarily related to net operating loss carryforwards. 

 

The Company has not recorded any amounts for unrecognized tax benefits as of December 31, 2017 or 2016.

 

The Company files tax returns as prescribed by the tax laws of the jurisdictions in which it operates. In the normal course of business, the Company is subject to examination by federal and state jurisdictions, where applicable. There are currently no pending income tax examinations. The Company’s tax years are still open under statute from December 31, 2014 to the present. Earlier years may be examined to the extent that tax credit or net operating loss carryforwards are used in future periods. The Company’s policy is to record interest and penalties related to income taxes as part of its income tax provision.    As of December 31, 2017 and 2016, the Company had no accrued interest or penalties related to uncertain tax positions and no amounts have been recognized in the Company’s statements of operations and comprehensive loss.