Entity information:

11.      Income Taxes

The components of the Company’s loss before income taxes were as follows (in thousands):

 

 

 

Year Ended December 31,

 

 

 

2017

 

 

2016

 

 

2015

 

Domestic

 

$

250,917

 

 

$

192,287

 

 

$

145,618

 

Foreign

 

 

67,421

 

 

 

53,552

 

 

 

 

Total loss before income taxes

 

$

318,338

 

 

$

245,839

 

 

$

145,618

 

 


The components of the Company’s income tax provision were as follows (in thousands):

 

 

Year Ended December 31,

 

 

 

 

2017

 

 

2016

 

 

2015

 

 

Current provision for income taxes:

 

 

 

 

 

 

 

 

 

 

 

 

 

Federal

 

$

 

 

$

 

 

$

 

 

State

 

 

5

 

 

 

 

 

 

 

 

International

 

 

42

 

 

 

35

 

 

 

 

 

Total current tax provision

 

 

47

 

 

 

35

 

 

 

 

 

Deferred tax benefit:

 

 

 

 

 

 

 

 

 

 

 

 

 

Federal

 

 

(16,243

)

 

 

 

 

 

 

 

State

 

 

(3

)

 

 

 

 

 

 

 

International

 

 

 

 

 

 

 

 

 

 

Total deferred tax benefit

 

 

(16,246

)

 

 

 

 

 

 

 

Total (benefit from) provision for income

    taxes

 

$

(16,199

)

 

$

35

 

 

$

 

 

The Company has incurred net operating losses since inception. The Company has not reflected any benefit of such net operating loss carryforwards in the accompanying financial statements. The Company has established a full valuation allowance against its deferred tax assets due to the uncertainty surrounding the realization of such assets.

The effective tax rate of our provision for income taxes differs from the federal statutory rate as follows:

 

 

 

Year Ended December 31,

 

 

 

 

2017

 

 

2016

 

 

2015

 

 

Federal statutory income tax rate

 

 

34.0

 

%

 

34.0

 

%

 

34.0

 

%

State income taxes, net of federal benefit

 

 

 

 

 

1.3

 

 

 

7.5

 

 

Federal tax credits

 

 

9.0

 

 

 

13.7

 

 

 

5.9

 

 

Other

 

 

(0.9

)

 

 

(0.3

)

 

 

0.8

 

 

Nondeductible permanent items

 

 

 

 

 

 

 

 

 

 

Stock-based compensation

 

 

(0.6

)

 

 

(1.4

)

 

 

(1.3

)

 

Uncertain tax positions

 

 

(1.8

)

 

 

2.0

 

 

 

(7.7

)

 

Change in valuation allowance

 

 

(32.5

)

 

 

(41.9

)

 

 

(39.2

)

 

Foreign rate differential

 

 

(7.2

)

 

 

(7.4

)

 

 

 

 

Change in federal tax rate

 

 

5.1

 

 

 

 

 

 

 

 

Provision for income taxes

 

 

5.1

 

 

 

 

 

 

 

 

 

The tax effect of temporary differences that give rise to significant portions of the deferred tax assets is presented below (in thousands):

 

 

 

Year Ended December 31,

 

 

 

 

2017

 

 

2016

 

 

Deferred tax assets:

 

 

 

 

 

 

 

 

 

Loss carryforwards

 

$

154,949

 

 

$

102,960

 

 

Tax credits

 

 

119,542

 

 

 

78,324

 

 

Stock options

 

 

21,336

 

 

 

16,084

 

 

Accruals and reserves

 

 

5,939

 

 

 

10,039

 

 

Fixed assets and intangibles

 

 

1,194

 

 

 

3,014

 

 

Other

 

 

1,286

 

 

 

1,950

 

 

Gross deferred tax assets

 

 

304,246

 

 

 

212,371

 

 

Valuation allowance

 

 

(304,246

)

 

 

(212,371

)

 

Total deferred tax assets

 

 

 

 

 

 

 

Deferred tax liabilities:

 

 

 

 

 

 

 

 

 

In-process research and development

 

 

(31,166

)

 

 

 

 

Net deferred tax assets (liabilities)

 

$

(31,166

)

 

$

 

 

 

  

As of December 31, 2017 and 2016, the Company had $422.3 million and $315.5 million of federal net operating loss carryforwards available to reduce future taxable income that will begin to expire in 2030. As of December 31, 2017 and 2016, the Company had $457.7 million and $259.8 million of state net operating loss carryforwards available to reduce future taxable income that will begin to expire in 2030.

As of December 31, 2017 and 2016, the Company had federal research tax credit carryforwards of $4.5 million and $2.5 million available to reduce future tax liabilities that will begin to expire in 2030. As of December 31, 2017 and 2016, the Company had state research credit carryforwards of $12.4 million and $6.7 million available to reduce future tax liabilities that will be carried forward indefinitely.

As of December 31, 2017 and 2016, the Company had federal Orphan Drug Credits of $124.6 million and $84.3 million available to reduce future tax liabilities that will begin to expire in 2031.

The Company’s ability to use net operating loss and tax credit carryforwards to reduce future taxable income and liabilities may be subject to annual limitations pursuant to Internal Revenue Code Sections 382 and 383 as a result of ownership changes in the past and future. As a result of ownership changes in 2012 and 2011, $3.6 million of federal net operating loss carryforwards, $3.6 million of state net operating loss carryforwards, and $0.2 million of federal tax credits are permanently limited. Deferred tax assets for net operating losses and tax credits have been reduced and a corresponding adjustment to the valuation allowance has been recorded.

On November 7, 2017, the Company acquired Dimension (see Note 3 “Acquisition”). The Company recorded a $47.4 million deferred tax liability relating to the tax impact of future GAAP amortization or potential impairments associated with the identified intangible assets acquired, which are indefinitely lived assets and are not currently deductible for tax purposes. Due to the reduction of the US corporate tax rate to 21% in the period subsequent to the acquisition, the Company recorded a net decrease to the deferred tax liability of $16.2 million with a corresponding benefit from income taxes of $16.2 million for the year ended December 31, 2017.  

The valuation allowance increased by $91.9 million and $102.9 million during the year ended December 31, 2017 and 2016, respectively.

On December 22, 2017, the U.S. government enacted comprehensive tax legislation commonly referred to as the Tax Cuts and Jobs Act (Tax Act). The Company has calculated its best estimate of the impact of the Tax Act in its year end income tax provision in accordance with its understanding of the Tax Act and guidance available as of the date of this filing. The provisional amount related to the remeasurement of certain deferred tax assets and liabilities based on the rates at which they are expected to reverse in the future was a net decrease related to deferred tax assets and deferred tax liabilities of $70.5 million, with a corresponding net adjustment to benefit from income taxes of $16.1 million and offsetting change in valuation allowance of $86.6 million for the year ended December 31, 2017. The Company does not expect a material impact related to the one-time transition tax on the mandatory deemed repatriation of foreign earnings.

On December 22, 2017, Staff Accounting Bulletin No. 118 (SAB 118) was issued to address the application of GAAP in situations when a registrant does not have the necessary information available, prepared, or analyzed (including computations) in reasonable detail to complete the accounting for certain income tax effects of the Act. In accordance with SAB 118, the Company has determined that the adjustment to deferred taxes was a provisional amount and a reasonable estimate at December 31, 2017. The determination of the benefit from (provision for) income taxes requires complex estimations, significant judgments and significant knowledge and experience concerning the applicable tax laws. Given that the Company is still in the transition period for the accounting for income tax effects of the Tax Act, the current assessment on deferred tax assets (liabilities) is based on the currently available information and guidance. If in the future any element of the tax reform changes the related accounting guidance for income tax, it could affect the Company’s income tax position and the Company may need to adjust the benefit from (provision for) income taxes accordingly.

The Company recorded unrecognized tax benefits for uncertainties in income taxes. A reconciliation of the Company’s unrecognized tax benefits for the years ended December 31, 2017, 2016, and 2015 is as follows (in thousands):

 

 

 

December 31,

 

 

 

2017

 

 

2016

 

 

2015

 

Balance at beginning of year

 

$

13,505

 

 

$

24,010

 

 

$

7,275

 

Additions based on tax positions related to current

   year

 

 

9,338

 

 

 

6,777

 

 

 

15,628

 

Additions for tax positions of prior years

 

 

5,534

 

 

 

877

 

 

 

5,505

 

Reductions for tax positions of prior years

 

 

 

 

 

(18,159

)

 

 

(4,398

)

Balance at end of year

 

$

28,377

 

 

$

13,505

 

 

$

24,010

 

  

The entire amount of the unrecognized tax benefits would not impact the Company’s effective tax rate if recognized. The Company has elected to include interest and penalties as a component of tax expense. During the years ended December 31, 2017 and 2016, the Company did not recognize accrued interest and penalties related to unrecognized tax benefits. The Company does not anticipate that the amount of existing unrecognized tax benefits will significantly increase or decrease during the next year.

It is our intention to reinvest the earnings of our non-U.S. subsidiaries in their operations. As of December 31, 2017, the Company had not made a provision for U.S. income taxes or foreign withholding taxes on a nominal amount of the excess of the amount of net income for financial reporting over the tax basis of investments in foreign subsidiaries that are essentially permanent in duration. Generally, such amounts become subject to U.S. taxation upon repatriation as dividends and under certain other circumstances. If these earnings were repatriated to the U.S., the deferred tax liability associated with these temporary differences would result in a nominal amount.

The Company files income tax returns in the U.S. federal, California, and other state tax jurisdictions. The federal and state income tax returns from inception to December 31, 2017 remain subject to examination.